Programming cell communications with pH-responsive DNA nanodevices dagger
PUBLICATION: CHEMICAL COMMUNICATIONS
AUTHORS: Hou, JJ; Zhu, ST; Zhao, ZW; Shen, JL; Chao, J; Shi, JY; Li, J; Wang, LH; Ge, ZL; Li, Q
ABSTRACT
DNA nanoswitches on cell surfaces could respond to changes of pH under physiological conditions by switching from a three-chain structure to a double-chain structure, thus connecting another set of cells modified with complementary single-stranded DNA. This pH-triggered cell communication offers a promising approach for cell-based therapy under a tumor microenvironment.
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