A nano-integrated microfluidic biochip for enzyme-based point-of-care detection of creatinine
PUBLICATION: CHEMICAL COMMUNICATIONS
AUTHORS: Li, JY; Li, ZH; Dou, YZ; Su, J; Shi, JY; Zhou, Y; Wang, LH; Song, SP; Fan, CH
ABSTRACT
A nano-integrated portable enzymatic microfluidic electrochemical biochip was developed for single-step point-of-care testing of creatinine. The biochip could automatically eliminate a lot of interferences from practical biological samples and enzymatic intermediate products. Gold nanostructure- and carbon nanotube-based screen-printed carbon electrodes were integrated into microfluidic structures to improve the detection performance for creatinine. The microfluidic electrochemical biochip holds promise to become a practical device for medical diagnosis, especially POCT.
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